2022 J Neurotrauma 39(23-24):1678-1686 Systemic Immune Profile Predicts the Development of Infections in Patients with Spinal Cord Injuries

Inflammatory markers in subacute human sera (30 days after spinal cord injury) may predict the development of infection in SCI patients.

We show here that in incomplete lesions (AIS C and D grades), the levels of eotaxin-1 (CCL11), and the number of lymphocytes, basophils and monocytes are predictive of lower odds for infections. On the other hand, the number of neutrophils and eosinophils as well as, in a lesser extent, the levels of IP-10 (CXCL10), MCP-1 (CCL2), BDNF and VEGF-A are predictors of increased susceptibility for developing infections.