1. THE EPENDYMAL REGION IN HUMAN SPINAL CORD. COMPARATIVE STUDIES AND RELATION TO INJURY

1. THE EPENDYMAL REGION IN HUMAN SPINAL CORD. COMPARATIVE STUDIES AND RELATION TO INJURY

We aim to study the neural stem cells and neural precursors in the spinal cord of different species, including humans. We would like to contribute not only to the biology of those cells but also to the understanding of the structure and functional organization of the niche in normal and pathological conditions.

Works funded by Wings For Life Foundation and Fundacion Mutua Madrileña

PUBLICATIONS:

2022. Torrillas de la Cal A, Paniagua-Torija B, Arevalo-Martin A, Faulkes CG, Jimenez AJ, Ferrer I, Molina-Holgado E, Garcia-Ovejero D. The structure of the Spinal Cord Ependymal Region in Adult Humans is a distinctive trait among mammals. Cells. 2021 10(9):2235

2018. Paniagua-Torija B, Norenberg M, Arevalo-Martin A, Carballosa-Gautam MM, Campos-Martin Y, Molina-Holgado E, Garcia-Ovejero D.. Cells in the adult human spinal cord ependymal region do not proliferate after injury. J Pathol. 2018 Aug 8. doi: 10.1002/path.5151. [Epub ahead of print]

2018. Garcia-Ovejero D, Paniagua-Torija B, Arevalo-Martin A, Navarro-Galve B, Molina-Holgado E. Laser-Capture Microdissection for the Analysis of Rat and Human Spinal Cord Ependyma by qPCR   Methods in Mol Biol. 2018;1723:285-318.

2017. Gonzalez-Fernandez C, Arevalo-Martin A, Paniagua-Torija B, Ferrer I, Rodriguez FJ, Garcia-Ovejero D. Wnts Are Expressed in the Ependymal Region of the Adult Spinal Cord. Mol Neurobiol. 2017. 54(8):6342-6355..

2015. Paniagua-Torija B, Arevalo-Martin A, Ferrer I, Molina-Holgado E, Garcia-Ovejero D.  CB1 cannabinoid receptor enrichment in the ependymal region of the adult human spinal cord. Scientific Reports. 5, Article number: 17745 (2015). doi:10.1038/srep17745

2015. Garcia-Ovejero D, Arevalo-Martin A, Paniagua-Torija B, Florensa-Vila J, Ferrer I, Grassner L, Molina-Holgado E. The ependymal region of the adult human spinal cord differs from other species and shows ependymoma-like features. Brain. 2015 Jun;138(Pt 6):1583-97.

2015. Paniagua-Torija B, Arevalo-Martin A, Molina-Holgado E, Molina-Holgado F, Garcia-Ovejero D. Spinal cord injury induces a long-lasting upregulation of interleukin-1β in astrocytes around the central canal. Neuroscience. 2015 Jan 22;284:283-9. doi: 10.1016/j.neuroscience.2014.10.013. Epub 2014 Oct 19.

2013. Garcia-Ovejero D, Arevalo-Martin A, Paniagua-Torija B, Sierra-Palomares Y, Molina-Holgado E. A cell population that strongly expresses the CB1 cannabinoid receptor in the ependyma of the rat spinal cord. J Comp Neurol. 2013 Jan 1;521(1):233-51.