2024 Untargeted blood serum proteomics identifies novel proteins related to neurological recovery after human spinal cord injury

New work in collaboration with our friends at Murnau Trauma Center and Paracelsus University, showing serum proteins related with neurological recovery.

We used a proteomics strategy of high and medium abundant protein depletion for uncovering new low abundant proteins differentially expressed between patients with strong or no recovery between 30 and 120 days after SCI.

We found that recovery is associated with an enrichment in proteins involved in inflammation, coagulation, and lipid metabolism. Technical validation using commercial ELISAs further confirms that high levels of SERPINE1 and ARHGAP35 are associated with strong neurological recovery, while high levels of CD300a and DEFA1 are associated with lack of recovery.