Neuroinflammation Laboratory, Hospital Nacional de Parapléjicos
SELECTED WORKS
2018 J Pathol. 246(4):415-421. Cells in the adult human spinal cord ependymal region do not proliferate after injury.
We show here for the first time that there is no proliferation in the ependymal region of the human spinal cord after Spinal cord injury, regardless the time after lesion and distance from the epicenter. This may question this region as a neurogenic niche and a source of new cells after damage in...
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2022 Cells 10(9):2235. The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals.
We describe the uniqueness of the human ependymal region in the spinal cord, comparing it with that of other mammals. We describe here in detail the ependymal region of the naked mole rat and hyh mutant mice, and also show some new data on the process of central canal disassembling in humans, in...
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2018 Front Immunol. 9:2365. Elevated Autoantibodies in Subacute Human Spinal Cord Injury Are Naturally Occurring Antibodies.
A very relevant contribution to the field of SCI immunology:
We provide a plausible explanation for the joint appearance of SCI induced immunodepression and autoimmunity: the existence of natural autoantibodies. We describe here new specificities that notably increases 4 weeks after injury, many of...
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2022 J Neurotrauma. 39(9-10):613-626. A New Score Based on the International Standards for Neurological Classification of Spinal Cord Injury for Integrative Evaluation of Changes in Sensorimotor Functions.
Terrific work in which I had the luck to participate. It was conceived, developed and coordinated by my colleague and friend Angel Arevalo-Martin, and describes a new composed score of neurological changes between two time points in SCI patients. It is much more sensitive than current evaluations...
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2022 J Neurotrauma 39(23-24):1678-1686 Systemic Immune Profile Predicts the Development of Infections in Patients with Spinal Cord Injuries
Inflammatory markers in subacute human sera (30 days after spinal cord injury) may predict the development of infection in SCI patients.
We show here that in incomplete lesions (AIS C and D grades), the levels of eotaxin-1 (CCL11), and the number of lymphocytes, basophils and monocytes are...
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2024 Untargeted blood serum proteomics identifies novel proteins related to neurological recovery after human spinal cord injury
New work in collaboration with our friends at Murnau Trauma Center and Paracelsus University, showing serum proteins related with neurological recovery.
We used a proteomics strategy of high and medium abundant protein depletion for uncovering new low abundant proteins differentially expressed...
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2023 Glia. 2023 Jan;71(1):91-102. Endocannabinoid signaling in oligodendroglia.
Reviewing the state of the art of the expression and role of different component of the Endocannabinoid system and their relatives in the biology of oligodendrocytes
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