PAST_1> THE ENDOCANNABINOID SYSTEM, MYELIN AND SPINAL CORD INJURY

Homepage > PAST_1> THE ENDOCANNABINOID SYSTEM, MYELIN AND SPINAL CORD INJURY

Endocannabinoids are produced in spinal cord after contusion,

Acute blockade of cannabinoid receptors hampers spontaneous recovery

Exogenous administration of 2-arachidonoylglycerol early after spinal cord contusion limits the extension of secondary damage.

Partly funded by Fundacion Mutua Madrileña

PUBLICATIONS:

2015. García-Ovejero D, Arévalo-Martín Á, Navarro-Galve B, Pinteaux E, Molina-Holgado E, Molina-Holgado F. Neuroimmmune interactions of cannabinoids in neurogenesis: focus on interleukin-1β (IL-1β) signalling. Biochem Soc Trans. 2013 Dec;41(6):1577-82. doi: 10.1042/BST20130198. Review.

2015. Cannabinoids to treat spinal cord injury.Arevalo-Martin A, Molina-Holgado E, Garcia-Ovejero D. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 21. pii: S0278-5846(15)00057-3. doi: 10.1016/j.pnpbp.2015.03.008.

2013. Garcia-Ovejero D, Arevalo-Martin A, Paniagua-Torija B, Sierra-Palomares Y, Molina-Holgado E. A cell population that strongly expresses the CB1 cannabinoid receptor in the ependyma of the rat spinal cord. J Comp Neurol. 521(1):233-51.

2012. Arevalo-Martin A, Garcia-Ovejero D, Sierra-Palomares Y, Paniagua-Torija B, Gonzalez-Gil I, Ortega-Gutierrez S, Molina-Holgado E. Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery.PLoS One. 7(11):e49057. doi: 10.1371/journal.pone.0049057.

2012. Oliviero A, Arevalo-Martin A, Rotondi M, García-Ovejero D, Mordillo-Mateos L, Lozano-Sicilia A, Panyavin I, Chiovato L, Aguilar J, Foffani G, Di Lazzaro V, Molina-Holgado E. CB1 receptor antagonism/inverse agonism increases motor system excitability in humans. Eur Neuropsychopharmacol. 22(1):27-35.

2010. Arevalo-Martin A, Garcia-Ovejero D, Molina-Holgado E. The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury. Neurobiol Dis. 38(2):304-12.

2009.Garcia-Ovejero D, Arevalo-Martin A, Petrosino S, Docagne F, Hagen C, Bisogno T, Watanabe M, Guaza C, Di Marzo V, Molina-Holgado E. The endocannabinoid system is modulated in response to spinal cord injury in rats.Neurobiol Dis. 33(1):57-71.

2008. Rubio-Araiz A, Arévalo-Martín A, Gómez-Torres O, Navarro-Galve B, García-Ovejero D, Suetterlin P, Sánchez-Heras E, Molina-Holgado E, Molina-Holgado F. The endocannabinoid system modulates a transient TNF pathway that induces neural stem cell proliferation. Mol Cell Neurosci. 2008 Jul;38(3):374-80.

2007. Arévalo-Martín A, García-Ovejero D, Rubio-Araiz A, Gómez O, Molina-Holgado F, Molina-Holgado E. Cannabinoids modulate Olig2 and polysialylated neural cell adhesion molecule expression in the subventricular zone of post-natal rats through cannabinoid receptor 1 and cannabinoid receptor 2. Eur J Neurosci. 26(6):1548-59.

Funded by Fundacion Mutua Madrileña, Gobierno de Castilla La Mancha and Instituto de Salud Carlos III: