Neuroinflammation Laboratory, Hospital Nacional de Parapléjicos
SELECTED WORKS
2015 Brain. 138(Pt 6):1583-97 The ependymal region of the adult human spinal cord differs from other species and shows ependymoma-like features
2016 Prog Neuropsychopharmacol Biol Psychiatry. 64:190-9. Cannabinoids to treat spinal cord injury.
2017 Mol Neurobiol. 54(8):6342-6355. Wnts Are Expressed in the Ependymal Region of the Adult Spinal Cord.
2018 J Pathol. 246(4):415-421. Cells in the adult human spinal cord ependymal region do not proliferate after injury.
We show here for the first time that there is no proliferation in the ependymal region of the human spinal cord after Spinal cord injury, regardless the time after lesion and distance from the epicenter. This may question this region as a neurogenic niche and a source of new cells after damage in...
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2018 Front Immunol. 9:2365. Elevated Autoantibodies in Subacute Human Spinal Cord Injury Are Naturally Occurring Antibodies.
A very relevant contribution to the field of SCI immunology:
We provide a plausible explanation for the joint appearance of SCI induced immunodepression and autoimmunity: the existence of natural autoantibodies. We describe here new specificities that notably increases 4 weeks after injury, many of...
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2021 J Neurochem 158(3):640-656. Cannabinoid Receptor 1 associates to different molecular complexes during GABAergic neuron maturation.
We studied the interactome of CB1 receptor by proteomics during GABA neuron maturation. We describe new partners of this receptor that may be relevant to understand cannabinoid actions on neuronal development (DLAT, FASN, YWHAZ, VDAC1, MPRIP, USHBP1) and that the interactome of CB1 is enriched at...
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2021 Mol Neurobiol. 58(2):689-702. Heterogeneity of the Endocannabinoid System Between Cerebral Cortex and Spinal Cord Oligodendrocytes.
We describe here 2 relevant data:
1- A method for obtaining high yield and high purity OPC and oligodendrocyte primary cultures
2- The description of heterogeneity in expression of endocannabinoid system components
in spinal vs cortical OPC and oligodendrocytes
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2023 Glia. 2023 Jan;71(1):91-102. Endocannabinoid signaling in oligodendroglia.
Reviewing the state of the art of the expression and role of different component of the Endocannabinoid system and their relatives in the biology of oligodendrocytes
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2022 Cells 10(9):2235. The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals.
We describe the uniqueness of the human ependymal region in the spinal cord, comparing it with that of other mammals. We describe here in detail the ependymal region of the naked mole rat and hyh mutant mice, and also show some new data on the process of central canal disassembling in humans, in...
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